Highlights - All about the Adrenals
Original Articles focusing on adrenal gland biology
Scroll down for reviews and other articles focusing on brain and liver biology
2025
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Dumontet T, Basham KJ, Foster MC, Silverman E, Heard KA, Johnson D, Lee C, Plaska SW, Breault DT, Penton D, Beuschlein F, Turcu AF, LaPensee CR, Marcondes Lerario A, Hammer GD. The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion. Res Sq [Preprint]. 2025 Apr 15:rs.3.rs-6248794. doi: 10.21203/rs.3.rs-6248794/v1. PMID: 40321776; PMCID: PMC12047992.
2024
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Borges KS, Little DW 3rd, Magalhães TA, Ribeiro C, Dumontet T, Lapensee C, Basham KJ, Seth A, Azova S, Guagliardo NA, Barrett PQ, Berber M, O'Connell AE, Turcu AF, Lerario AM, Mohan DR, Rainey W, Carlone DL, Hirschhorn JN, Salic A, Breault DT, Hammer GD. Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production. bioRxiv [Preprint]. 2024 Aug 24:2024.08.23.609423. doi: 10.1101/2024.08.23.609423. PMID: 39229119; PMCID: PMC11370552.
2022
Dufour D, Dumontet T, Sahut-Barnola I, Carusi A, Onzon M, Pussard E, Wilmouth JJ, Olabe J, Lucas C, Levasseur A, Damon-Soubeyrand C, Pointud JC, Roucher-Boulez F, Tauveron I, Bossis G, Yeh ET, Breault DT, Val P, Lefrançois-Martinez AM, Martinez A. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice. Nat Commun. 2022 Dec 21;13(1):7858. doi: 10.1038/s41467-022-35526-5. PMID: 36543805; PMCID: PMC9772323.
2019
Dumontet T, Sahut-Barnola I, Dufour D, Lefrançois-Martinez AM, Berthon A, Montanier N, Ragazzon B, Djari C, Pointud JC, Roucher-Boulez F, Batisse-Lignier M, Tauveron I, Bertherat J, Val P, Martinez A. Hormonal and spatial control of SUMOylation in the human and mouse adrenal cortex. FASEB J. 2019 Sep;33(9):10218-10230. doi: 10.1096/fj.201900557R. Epub 2019 Jun 17. PMID: 31208233.
2018
Mathieu M, Drelon C, Rodriguez S, Tabbal H, Septier A, Damon-Soubeyrand C, Dumontet T, Berthon A, Sahut-Barnola I, Djari C, Batisse-Lignier M, Pointud JC, Richard D, Kerdivel G, Calméjane MA, Boeva V, Tauveron I, Lefrançois-Martinez AM, Martinez A, Val P. Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12265-E12274. doi: 10.1073/pnas.1809185115. Epub 2018 Dec 12. PMID: 30541888; PMCID: PMC6310834.
2018
Dumontet T, Sahut-Barnola I, Septier A, Montanier N, Plotton I, Roucher-Boulez F, Ducros V, Lefrançois-Martinez AM, Pointud JC, Zubair M, Morohashi KI, Breault DT, Val P, Martinez A. PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal. JCI Insight. 2018 Jan 25;3(2):e98394. doi: 10.1172/jci.insight.98394. PMID: 29367455; PMCID: PMC5821213.
2017
Batisse-Lignier M, Sahut-Barnola I, Tissier F, Dumontet T, Mathieu M, Drelon C, Pointud JC, Damon-Soubeyrand C, Marceau G, Kemeny JL, Bertherat J, Tauveron I, Val P, Martinez A, Lefrançois-Martinez AM. P53/Rb inhibition induces metastatic adrenocortical carcinomas in a preclinical transgenic model. Oncogene. 2017 Aug;36(31):4445-4456. doi: 10.1038/onc.2017.54. Epub 2017 Apr 3. PMID: 28368424.
2016
Drelon C, Berthon A, Sahut-Barnola I, Mathieu M, Dumontet T, Rodriguez S, Batisse-Lignier M, Tabbal H, Tauveron I, Lefrançois-Martinez AM, Pointud JC, Gomez-Sanchez CE, Vainio S, Shan J, Sacco S, Schedl A, Stratakis CA, Martinez A, Val P. PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development. Nat Commun. 2016 Sep 14;7:12751. doi: 10.1038/ncomms12751. PMID: 27624192; PMCID: PMC5027289.
2016
Vidal V, Sacco S, Rocha AS, da Silva F, Panzolini C, Dumontet T, Doan TM, Shan J, Rak-Raszewska A, Bird T, Vainio S, Martinez A, Schedl A. The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3. Genes Dev. 2016 Jun 15;30(12):1389-94. doi: 10.1101/gad.277756.116. Epub 2016 Jun 16. PMID: 27313319; PMCID: PMC4926862.
2016
Drelon C, Berthon A, Mathieu M, Ragazzon B, Kuick R, Tabbal H, Septier A, Rodriguez S, Batisse-Lignier M, Sahut-Barnola I, Dumontet T, Pointud JC, Lefrançois-Martinez AM, Baron S, Giordano TJ, Bertherat J, Martinez A, Val P. EZH2 is overexpressed in adrenocortical carcinoma and is associated with disease progression. Hum Mol Genet. 2016 Jul 1;25(13):2789-2800. doi: 10.1093/hmg/ddw136. Epub 2016 May 5. PMID: 27149985; PMCID: PMC6095221.
2014
de Joussineau C, Sahut-Barnola I, Tissier F, Dumontet T, Drelon C, Batisse-Lignier M, Tauveron I, Pointud JC, Lefrançois-Martinez AM, Stratakis CA, Bertherat J, Val P, Martinez A. mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD). Hum Mol Genet. 2014 Oct 15;23(20):5418-28. doi: 10.1093/hmg/ddu265. Epub 2014 May 27. PMID: 24865460; PMCID: PMC4184389.
Brain and Liver
Original Articles focusing on other organs
2023
Cheung LYM, Menage L, Rizzoti K, Hamilton G, Dumontet T, Basham K, Daly AZ, Brinkmeier ML, Masser BE, Treier M, Cobb J, Delogu A, Lovell-Badge R, Hammer GD, Camper SA. Novel Candidate Regulators and Developmental Trajectory of Pituitary Thyrotropes. Endocrinology. 2023 Apr 17;164(6):bqad076. doi: 10.1210/endocr/bqad076. PMID: 37183548; PMCID: PMC10227867.
2022
Amaya JM, Viho EMG, Sips HCM, Lalai RA, Sahut-Barnola I, Dumontet T, Montanier N, Pereira AM, Martinez A, Meijer OC. Gene expression changes in the brain of a Cushing's syndrome mouse model. J Neuroendocrinol. 2022 Apr;34(4):e13125. doi: 10.1111/jne.13125. Epub 2022 Apr 1. PMID: 35365898; PMCID: PMC9287025.
2021
Amaya JM, Suidgeest E, Sahut-Barnola I, Dumontet T, Montanier N, Pagès G, Keller C, van der Weerd L, Pereira AM, Martinez A, Meijer OC. Effects of Long-Term Endogenous Corticosteroid Exposure on Brain Volume and Glial Cells in the AdKO Mouse. Front Neurosci. 2021 Feb 10;15:604103. doi: 10.3389/fnins.2021.604103. PMID: 33642975; PMCID: PMC7902940.
2015
Just PA, Poncy A, Charawi S, Dahmani R, Traore M, Dumontet T, Drouet V, Dumont F, Gilgenkrantz H, Colnot S, Terris B, Coulouarn C, Lemaigre F, Perret C. LKB1 and Notch Pathways Interact and Control Biliary Morphogenesis. PLoS One. 2015 Dec 21;10(12):e0145400. doi: 10.1371/journal.pone.0145400. PMID: 26689699; PMCID: PMC4687046.
Reviews & Commentary
Reviews and Commentary
Adrenal androgens, adrenarche and zona reticularis:
A human affair?
Dumontet T, Martinez A. Mol Cell Endocrinol. 2021
doi:10.1016/j.mce.2021.111239. PMID: 33676986.
Adrenocortical development: Lessons from mouse models
Dumontet T, Sahut-Barnola I, Septier A, Montanier N, Plotton I, Roucher-Boulez F, Ducros V, Lefrançois-Martinez AM, Pointud JC, Zubair M, Morohashi KI, Breault DT, Val P, Martinez A.
Ann Endocrinol (Paris). 2018
doi: 10.1016/j.ando.2018.03.014. PMID: 29673697.
Bones and adrenal organogenesis: how embryonic osteocalcin influences lifelong adrenal function
Dumontet T, Hammer GD. J Clin Invest. 2022
doi: 10.1172/JCI157200. PMID: 35166237
β-catenin in adrenal zonation and disease
Little DW 3rd, Dumontet T, LaPensee CR, Hammer GD.
Mol Cell Endocrinol. 2021
doi:10.1016/j.mce.2020.111120. PMID: 33338548
Adrenocortical stem cells in health and disease
Chu Y, Setayesh J, Dumontet T, Krumeich L, Werner J, Moretti IF, De Sousa K, Kennedy C, La Pensee C, Lerario AM, Hammer GD.
Nat Rev Endocrinol. 2025
doi: 10.1038/s41574-025-01108-w. PMID: 40065108.